Cu(I)/amino acid catalyzed coupling reactions of aryl halides and nucleophiles: Applications in large-scale production

Abstract

Amino acids can be used as ligands to promote Ullmann-type coupling reactions. This review briefly discusses how L-proline, 4-hydroxy-L-proline and N,N-dimethylglycine can serve as the ideal ligands for coppercatalyzed coupling of aryl halides with different nucleophiles. Seven examples of applications of copper/amino acid catalyzed reactions in large-scale preparations are described. © Schweizerische Chemische Gesellschaft.