Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage

Abstract

Sodium nitrite (NaNO 2) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10ml/kg infusions of either HBOC-201 or Hextend with and without NaNO 2. All vital signs, coagulation and blood chemistry were measured for 2hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8μmol/kg NaNO 2 infusion. Complete abolition was obtained with the highest 3 NaNO 2 dose, but side effects were observed. There was no reduction in platelet function due to NaNO 2. NaNO 2 ability to reduce HBOC-201 vasoactivity was transient and 10.8μmol/kg NaNO 2 seems an acceptable dose for further investigation. © 2011 Informa Healthcare USA, Inc.