Strong associations between inflammation, Pruritus and mental health in dialysis patients

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Abstract

Pruritus, impaired mental health and inflammation contribute to morbidity in end-stage renal disease. There are no studies on all 3 conditions. We therefore obtained inflammatory parameter data (C-reactive protein and interleukin-6), pruritus data and psychological test data (36-Item Short-Form Health Survey, “Allgemeine Depressionsskala” and Toronto Alexithymia Scale-20) for 19 dialysis patients with pruritus, 20 dialysis patients without pruritus and 15 healthy controls. Non-parametric hierarchical clustering revealed 3 clusters of parameters: one mainly driven by pruritus scores (chronic kidney disease-associated pruritus cluster), one by mental health scores (mental health cluster) and one by inflammatory parameters (inflammatory cluster). Factor analysis showed strong associations (mental health cluster/chronic kidney diseaseassociated pruritus cluster, r=–0.49; mental health cluster/inflammatory cluster, r=–0.52; inflammatory cluster/chronic kidney disease-associated pruritus cluster, r=0.48). For the first time, complete correlations between inflammation, mental health and pruritus in dialysis patients have been established. As all 3 conditions are associated with mortality, knowledge about their interdependence helps to understand endstage renal disease pathophysiology.

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Schricker, S., Heider, T., Schanz, M., Dippon, J., Alscher, M. D., Weiss, H., … Kimmel, M. (2019). Strong associations between inflammation, Pruritus and mental health in dialysis patients. Acta Dermato-Venereologica, 99(6), 524–529. https://doi.org/10.2340/00015555-3128

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