Curcumin suppresses colorectal cancer growth and metastasis by inhibiting NF-κB activity

Abstract

The third most malignant disease diagnosed worldwide is colorectal cancer (CRC). CRC treatment by chemo- and radiotherapy is challenging due to the cancer’s ability to activate major transcription factors such as NF-κB. Curcumin, a phytochemical, is known to downregulate NF-κB signaling in CRC cell lines and to exhibit anticarcinogenic properties. Therefore, curcumin and its analogues are novel therapeutic agents that could be used in the treatment of CRC growth and metastasis.