Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System

Abstract

The main objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of Letrozole (LTZ) intended for breast cancer therapy. LTZ loaded thiolated chitosan (TCS) nanoparticles were prepared by emulsion-solvent evaporation method. LTZ loaded TCS nanoaprticles were characterized by infrared spectra, drug entrapment efficiency and in vitro release. The system sustained release of LTZ significantly and further investigation could exhibit its potential usefulness in breast cancer therapy. The nanoparticles of LTZ prepared from TCS - may represent a useful approach for targeting its release at its site of absorption, sustaining its release.