Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders. © 2009 Nature Publishing Group All rights reserved.
CITATION STYLE
Revest, J. M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P. V., & Abrous, D. N. (2009). Adult hippocampal neurogenesis is involved in anxiety-related behaviors. Molecular Psychiatry, 14(10), 959–967. https://doi.org/10.1038/mp.2009.15
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