A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.
CITATION STYLE
Neumann, H., Sergeev, A. G., Spannenberg, A., & Beller, M. (2020). Efficient palladium-catalyzed synthesis of 2-aryl propionic acids. Molecules, 25(15). https://doi.org/10.3390/molecules25153421
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