Efficient palladium-catalyzed synthesis of 2-aryl propionic acids

5Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.

Cite

CITATION STYLE

APA

Neumann, H., Sergeev, A. G., Spannenberg, A., & Beller, M. (2020). Efficient palladium-catalyzed synthesis of 2-aryl propionic acids. Molecules, 25(15). https://doi.org/10.3390/molecules25153421

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free