New triterpenoids isolated from the root bark of Ulmus pumila L.

Abstract

Three new triterpenoids, 1-3, were isolated from the dried root bark of Ulmus pumila. Along with the three new compounds, six known triterpenoids, epifriedelanol (4), friedelin (5), oleanolic acid (6), maslinic acid (7), camaldulenic acid (8), and arjunolic acid (9) were also isolated. The structures of new compounds were established as ulmudiol (bauer-7-ene-1α,3β- diol, 1), dehydroulmudiol [bauer-7,9(11)-diene-1α,3β-diol, 2], and ulmuestone [3α-hydroxy-11α-(4′-hydroxy-3′-methoxy) benzoyloxybauer-1-one, 3], on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. In addition, the cytotoxic activities of these compounds are also reported. © 2006 Pharmaceutical Society of Japan.