The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species ( Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines. © 2013 Australian Society for Parasitology Inc.
CITATION STYLE
Williams, A. R., Zakutansky, S. E., Miura, K., Dicks, M. D. J., Churcher, T. S., Jewell, K. E., … Biswas, S. (2013). Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. International Journal for Parasitology, 43(11), 869–874. https://doi.org/10.1016/j.ijpara.2013.06.004
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