Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde

Abstract

Background: There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA). Aim: To clarify the association between vitiligo and SOD or MDA. Methods: Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI. Results: Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66–2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13–3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81–3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29–4.71, P < 0.001), compared with healthy controls. Conclusions: This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.