The founding member of the TRPP family, TRPP2, was identified as one of the disease genes causing autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most prevalent, potentially lethal, monogenic disorder in humans, with an average incidence of one in 400 to one in 1,000 individuals worldwide. Here we give an overview of TRPP ion channels and Polycystin-1 receptor proteins focusing on more recent studies. We include the Polycystin-1 family since these proteins are functionally linked to TRPP channels. © 2011 Springer Science+Business Media B.V.
CITATION STYLE
Hofherr, A., & Köttgen, M. (2011). TRPP channels and polycystins. In Advances in Experimental Medicine and Biology (Vol. 704, pp. 287–313). https://doi.org/10.1007/978-94-007-0265-3_16
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