Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo

  • Zou T
  • Satake A
  • Corbo-Rodgers E
  • et al.
32Citations
Citations of this article
62Readers
Mendeley users who have this article in their library.

Abstract

To ensure immune tolerance, regulatory T cell (Treg) numbers must be maintained by cell division. This process has been thought to be strictly dependent on the Treg TCR interacting with MHC class II. In this study, we report that Treg division does not absolutely require cell-autonomous TCR signaling in vivo, depending on the degree of IL-2–mediated stimulation provided. At steady state IL-2 levels, Tregs require cell-autonomous TCR signaling to divide. However, when given exogenous IL-2 or when STAT5 is selectively activated in Tregs, Treg division can occur independently of MHC class II and TCR signaling. Thus, depending on the amount of IL-2R stimulation, a wide range of TCR signals supports Treg division, which may contribute to preservation of a diverse repertoire of Treg TCR specificities. These findings also have therapeutic implications, as TCR signaling by Tregs may not be required when using IL-2 to increase Treg numbers for treatment of inflammatory disorders.

References Powered by Scopus

Homeostatic maintenance of natural Foxp3<sup>+</sup> CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

1058Citations
N/AReaders
Get full text

Interleukin-2 and regulatory T cells in graft-versus-host disease

939Citations
N/AReaders
Get full text

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

926Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Continuous requirement for the TCR in regulatory T cell function

423Citations
N/AReaders
Get full text

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

307Citations
N/AReaders
Get full text

Regulatory T-cell homeostasis: Steady-state maintenance and modulation during inflammation

181Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zou, T., Satake, A., Corbo-Rodgers, E., Schmidt, A. M., Farrar, M. A., Maltzman, J. S., & Kambayashi, T. (2012). Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo. The Journal of Immunology, 189(1), 28–32. https://doi.org/10.4049/jimmunol.1200507

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 27

52%

Researcher 17

33%

Professor / Associate Prof. 7

13%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 31

54%

Immunology and Microbiology 13

23%

Medicine and Dentistry 11

19%

Computer Science 2

4%

Save time finding and organizing research with Mendeley

Sign up for free