Acute reactions in dogs treated with doxorubicin: increased frequency with the use of a generic formulation.

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Abstract

During a 4-month period, 34 dogs with tumors received a total of 60 doses of a single generic formulation of doxorubicin; 13 acute drug reactions were observed in these 34 dogs, and no acute reactions were observed after replacing the product with the proprietary brand. These reactions were characterized by one or more of the following signs: pruritus; head-shaking; urticaria; erythema of the pinnal, axillary, or inguinal regions; vocalization; vomiting; hyperemic or pale mucous membranes; high heart rate; and high respiratory rate. We propose that a component unique to generic doxorubicin was responsible for the unusually high number of acute drug reactions observed.

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Phillips, B. S., Kraegel, S. A., Simonson, E., & Madewell, B. R. (1998). Acute reactions in dogs treated with doxorubicin: increased frequency with the use of a generic formulation. Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine, 12(3), 171–172. https://doi.org/10.1111/j.1939-1676.1998.tb02113.x

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