The Roles of Genetic and Epigenetic Aspects in Mandibular Prognathism: A Review

  • Zahro P
  • Ayu F
  • Jazaldi F
  • et al.
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Abstract

Individuals with mandibular prognathism (MP) are characterized by a concave facial profile, and in severe cases, an extremely long face. These clinical characteristics mostly result from the extreme forward growth of the mandible, and are more prevalent in Asians than in Caucasians. MP is a multifactorial condition, with genetic, environment or their interaction (including epigenetics) as assumed etiological factors. As suggested by familial and ethnic traits, the genetic aspects are important, and MP has been found to have a relationship with numerous loci and genes. The present review aims to assess studies on the potential association of MP with the candidate genes of MYO1H, RUNX2 and MATN1, and interactions between genes and environment. The results showed mechanisms of expression correlated genes developing MP. The interactions between these genes and others, or between the genes and the environment (epigenetics), have not been clearly demonstrated, except for the RUNX2 gene that correlates with observed K(lysine) acetyltransferase 6B (KAT6B) and histone deacetylase 4 (HDAC4). In conclusion, the expression of MYO1H, RUNX2, and MATN1 genes is indicated to play a vital role in genetic and epigenetic regulation to develop the phenotype of MP.

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APA

Zahro, P. F., Ayu, F. V., Jazaldi, F., & Auerkari, E. I. (2023). The Roles of Genetic and Epigenetic Aspects in Mandibular Prognathism: A Review. In Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021) (pp. 277–287). Atlantis Press International BV. https://doi.org/10.2991/978-94-6463-062-6_27

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