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Closed Loop Control of Perfusion Systems in High-density Cell Culture

  • Bock A
  • Reichl U
Springer Netherlands, (2007), 549-551
DOI: 10.1007/978-1-4020-5476-1_94
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Abstract

The use of a perfusion system prevented unspecific inhibitions effects on cell growth for batch cultivations of adherent MDCK cells used for an equine influenza A vaccine production process. It also increased viable cell numbers. An enzyme sensor for monitoring and closed loop control of metabolites operated stable for at least 55 hours.

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Bock, A., & Reichl, U. (2007). Closed Loop Control of Perfusion Systems in High-density Cell Culture. In Cell Technology for Cell Products (pp. 549–551). Springer Netherlands. https://doi.org/10.1007/978-1-4020-5476-1_94

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