Comparison of sequence analysis and the INNO-LiPA HBV DR line probe assay for detection of lamivudine-resistant hepatitis B virus strains in patients under various clinical conditions

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Abstract

A line probe assay (INNO-LiPA HBV DR) detecting drug-resistant hepatitis B virus (HBV) strains was evaluated. Results concordant with sequence analysis were obtained with 48 of 56 serum samples from HBV-infected patients undergoing lamivudine therapy. In eight cases, additional minor subpopulations could be identified by the line probe assay.

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Aberle, S. W., Kletzmayr, J., Watschinger, B., Schmied, B., Vetter, N., & Puchhammer-Stöckl, E. (2001). Comparison of sequence analysis and the INNO-LiPA HBV DR line probe assay for detection of lamivudine-resistant hepatitis B virus strains in patients under various clinical conditions. Journal of Clinical Microbiology, 39(5), 1972–1974. https://doi.org/10.1128/JCM.39.5.1972-1974.2001

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