An ERG gene analysis in two cases with metastatic castration-resistant prostate cancer in which abiraterone demonstrated long-term efficacy

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Abstract

We analyzed the ERG gene status using fluorescence in situ hybridization (FISH) in two chemotherapynaïve cases with metastatic castration-resistant prostate cancer (mCRPC) in which abiraterone demonstrated a long-term durable complete response. FISH identified Class 1 Edel and Class 2+ Edel in case 1, and Class 1 Edel in case 2. Our experience suggests that abiraterone may be effective in cases with mCRPC and ERG gene abnormalities, particularly Class 2+ Edel or Class 1 Edel. This is the first report of two cases with mCRPC that simultaneously investigated the ERG gene status and clinical aspects, including image evaluations and pathology.

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Yoshizawa, T., Yamaguchi, K., Kawata, N., Ryuzaki, H., Ogawa, M., Obinata, D., … Takahashi, S. (2020). An ERG gene analysis in two cases with metastatic castration-resistant prostate cancer in which abiraterone demonstrated long-term efficacy. Internal Medicine, 59(3), 395–399. https://doi.org/10.2169/internalmedicine.3302-19

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