SiRNA of DNA polymerase iota inhibits the migration and invasion in the lung cancer cell A549

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Abstract

DNA polymerase iota (poli) is a member of low-fidelity Y-family of DNA polymerases. Our previous studies have demonstrated that the overexpression of poli is associated with the poorer prognosis in lung cancer patients. Here, we designed the small interfering RNA (siRNA) targeting poli gene (POLI) to investigate the effect of poli on the proliferation, apoptosis, and invasion of the lung cancer cell line A549 in order to reveal the role of poli in lung cancer progression. Our results showed that siRNA of POLI had no significant effect on the proliferation and apoptosis of the lung cancer cell line A549. However, siRNA of POLI could inhibit the migration and invasion of the lung cancer cell line A549 by upregulating the E-cadherin expression and downregulating the expressions of N-cadherin, MMP2, and MMP9. Together, our findings indicate that poli plays a positive role in lung cancer progression via promoting the migration and invasion of lung cancer cells. Therefore, poli might be a potential target for the clinical treatment of lung cancer in the future.

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Li, L., Tian, H., Cheng, C., Li, S., Ming, L., & Qi, L. (2018). SiRNA of DNA polymerase iota inhibits the migration and invasion in the lung cancer cell A549. Acta Biochimica et Biophysica Sinica, 50(9), 929–933. https://doi.org/10.1093/abbs/gmy089

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