Spondyloarthritis, diffuse idiopathic skeletal hyperostosis (DISH) and chondrocalcinosis

Abstract

The authors describe the main clinical and radiological findings ofcommon enthesopathic disorders - spondylarthritis (SpA), chondrocalcinosis/calcium pyrophosphate dehydrate crystal deposition disease (CPPD CDD) and diffuse idiopathic skeletal hyperostosis (DISH), stressing similarities and differences which may help in the differential diagnosis. They emphasize the clinical presentation ofthe "pseudoankylosingspondylitis" forms of CPPD CDD. They also review the most relevant genes and molecular mechanisms associated with these conditions and with another enthesopathic disorder with high prevalence in the Japanese population-ossification of the posterior longitudinal ligament (OPLL). ©2009 Landes Bioscience and Springer Science+Business Media.