Synthesis and antifungal activity of some 2-benzothiazolylthioacetyl amino acid and peptide derivatives

Abstract

A series of benzothiazolylthioacetyl amino acid and peptide derivatives including glycoside, hydrazide and hydrazone moieties was synthesized with the aim of evaluating their antifungal activity. Their chemical structures were confirmed by 1H-NMR, IR, mass spectrometry and elemental analyses. Out of the thirty two tested compounds, three derivatives have high activity as fluconazole at 100 ppm and six at 1000 ppm toward Candida albicans, whereas they were inactive toward Aspergillus flavus. © ARKAT-USA, Inc.