The effectiveness and safety of topical β-receptor blocker in treating superficial infantile haemangiomas: A meta-analysis including 20 studies

Abstract

Aims: To evaluate the effectiveness and safety of topical β-receptor blocker in treating superficial infantile haemangiomas (SIH) and compare the effectiveness and safety of topical β-receptor blocker against other therapies. Methods: A search of the literature using PubMed, Embase, Cochrane Review database, China National Knowledge Infrastructure and Wanfang were performed to identify the studies that estimated the effectiveness and safety of topical β-receptor blocker in treating SIH, the fixed-effect or random-effects meta-analytical techniques were applied to assess the outcomes. Results: Twenty studies, involving 2098 patients, were included to conduct this analysis. Topical propranolol and topical timolol were discovered to be as effective as oral propranolol in treating SIH (propranolol, odds ratio [OR] = 0.486, 95% confidence interval [CI] 0.165, 1.426, P =.189; timolol, OR = 0.955; 95%CI 0.700, 1.302; P =.769), and topical timolol was more effective than topical imiquimod (OR = 2.561; 95%CI 1.182, 5.550; P =.017), observation (OR = 18.458; 95%CI 5.660, 60.191; P