Pharmacological Assessment of Anti-anaemic Activity of Aqueous Leaves Extracts of Telfairia occidentalis and Spondias mombin in Rats

Abstract

To investigate the anti-anaemic activity of aqueous leaves extracts of Telfairia occidentalis and Spondias mombin on experimental rats. The aqueous leaves extracts of T. occidentalis and S. mombin were obtained by cold maceration and processed for 48 h. The chloramphenicol model for experimental induction of anaemia in rats was employed. Anti-anaemic activity was determined by measuring haematological parameters of packed cell volume (PCV), haemeglobin count (Hb) and white blood cell count (WBC). The PCV and Hb levels of extracts treated rats were significantly (p < 0.05) increased compared to control group. The aqueous extract of T. occidentalis produces higher anti-anaemic activity compared to S. mombin. The decrease in WBC level was recorded with both extracts. The leaves extracts of T. occidentalis and S. mombin possess anti-anaemic activity, and validated their uses as haematinics by traditional healers.