Abstract
Neuropilins are receptors for all but one secreted (class 3) Semaphorins. The exception is Sema3E that directly binds and activates the Plexin-D1 receptor to induce cell repulsion. In this chapter, we review works that identified an unexpected role of Neuropilin-1 as a gating switch in Sema3E/Plexin-D1 signaling, that converts repulsion into attraction, and discuss the implications of this finding for brain wiring.
Cite
CITATION STYLE
Mann, F., & Chauvet, S. (2017). Neuropilin-dependent signaling and neuropilin-independent signaling of the guidance molecule Sema3E. In The Neuropilins: Role and Function in Health and Disease (pp. 75–89). Springer International Publishing. https://doi.org/10.1007/978-3-319-48824-0_5
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
