Case Report—Secondary Antibody Deficiency Due to Endogenous Hypercortisolism

2Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

Therapeutic corticosteroids have an immunosuppressive function involving several pathways, including lymphocytopenia and hypogammaglobulinemia. While these effects have been well-described in patients that received corticosteroids for therapeutic reasons, the effects of endogenous corticosteroids on the immune system are less well-understood. Here, we describe a 21-year old patient with hypercortisolism due to an ACTH producing thymic tumor. In this patient, we observed a decrease in some of the immunoglobulin classes, and in specific B and T cell populations that resembled effects caused by corticosteroid treatment. IgG levels were restored following treatment and normalization of the hypercortisolism.

References Powered by Scopus

Effects of corticosteroids on immunity in man. I. Decreased serum IgG concentration caused by 3 or 5 days of high doses of methylprednisolone

266Citations
N/AReaders
Get full text

Opportunistic infections in endogenous Cushing's syndrome

166Citations
N/AReaders
Get full text

Corticosteroid effect on immunoglobulins

147Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Estrogen, the Peripheral Immune System and Major Depression – A Reproductive Lifespan Perspective

9Citations
N/AReaders
Get full text

Corticosteroid-induced low immunoglobulin levels in multiple sclerosis — A confounding factor

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Sarcevic, J., Cavelti-Weder, C., Berger, C. T., & Trendelenburg, M. (2020). Case Report—Secondary Antibody Deficiency Due to Endogenous Hypercortisolism. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01435

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Researcher 1

25%

Readers' Discipline

Tooltip

Neuroscience 1

25%

Agricultural and Biological Sciences 1

25%

Medicine and Dentistry 1

25%

Arts and Humanities 1

25%

Save time finding and organizing research with Mendeley

Sign up for free