Therapeutic corticosteroids have an immunosuppressive function involving several pathways, including lymphocytopenia and hypogammaglobulinemia. While these effects have been well-described in patients that received corticosteroids for therapeutic reasons, the effects of endogenous corticosteroids on the immune system are less well-understood. Here, we describe a 21-year old patient with hypercortisolism due to an ACTH producing thymic tumor. In this patient, we observed a decrease in some of the immunoglobulin classes, and in specific B and T cell populations that resembled effects caused by corticosteroid treatment. IgG levels were restored following treatment and normalization of the hypercortisolism.
CITATION STYLE
Sarcevic, J., Cavelti-Weder, C., Berger, C. T., & Trendelenburg, M. (2020). Case Report—Secondary Antibody Deficiency Due to Endogenous Hypercortisolism. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01435
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