Transcription factors that regulate plant secondary metabolism are valuable tools for metabolic engineering and gene discovery. Related ERF-family transcription factors are required for jasmonate-inducible alkaloid biosynthesis in tobacco (Nicotiana tabacum) and periwinkle (Catharantus roseus). Transgenic manipulation of these ERF genes alters the expression of structural genes involved in the biosynthesis and transport of alkaloids, resulting in stimulation or inhibition of alkaloid accumulation. Novel enzymes and transporters can be identified by analyzing the expression profiles of genes that respond to these master regulators. The conserved jasmonate-responsive transcription factor MYC2 regulates the expression of alkaloid-specific ERF genes, thus placing alkaloid biosynthesis under the control of the jasmonate signaling pathway.
CITATION STYLE
Shoji, T., & Hashimoto, T. (2013). Jasmonate-responsive transcription factors: New tools for metabolic engineering and gene discovery. In Biotechnology for Medicinal Plants: Micropropagation and Improvement (Vol. 9783642299742, pp. 345–357). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-29974-2_15
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