The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical characteristics. Here, we describe a simple HPLC-based screening method to assess for developability factors earlier in the discovery process.
CITATION STYLE
Kohli, N., & Geddie, M. L. (2017). Novel HPLC-based screening method to assess developability of antibody-like molecules. In Methods in Molecular Biology (Vol. 1575, pp. 189–196). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6857-2_11
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