In humans, two endothelin receptors, ETa and ETb, are activated by three endogenous 21-mer cyclic peptides, ET-1, ET-2, and ET-3, which control various physiological processes, including vasoconstriction, vasodilation, and stimulation of cell proliferation. The first stage of this study it to produce a stable solubilized and purified receptor in a monodisperse state. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies.
CITATION STYLE
Mishin, A. V., Luginina, A. P., Potapenko, A. P., Borshchevskiy, V. I., Katritch, V., Edelweiss, E., … Cherezov, V. G. (2016). Expression and purification of an engineered human endothelin receptor B in a monomeric form. Doklady Biochemistry and Biophysics, 467(1), 157–161. https://doi.org/10.1134/S1607672916020216
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