Cardiovascular response to exogenous serotonin in healthy calves

Abstract

Objective - To characterize the cardiovascular response to IV administration of serotonin (5-hydroxytryptamine [5-HT]) in calves Animals - 5 healthy unsedated Friesian calves. Procedure - 41 5-HT administrations were performed: 11 slow infusions (duration, 5 minutes) and 30 bolus infusions (duration, 5 seconds) Cardiovascular function values were recorded before, during, and after the infusions. Results - Slow infusion of 5-HT first resulted in a brief period of severe bradycardia, then in sustained tachycardia with a concomitant increase in cardiac output. Systemic blood pressure response to 5-HT was triphasic, with initial hypotension concomitant with bradycardia, then a pressor phase associated with an increase in systemic vascular resistance, and finally, a long-lasting hypotensive phase associated with decreased systemic vascular resistance. Pulmonary hypertension was associated with increased pulmonary vascular resistance, reflecting intense pulmonary vasoconstriction Bolus infusion at increasing dosages resulted in dose-dependent bradycardia and systemic hypotension, followed by dose-dependent systemic hypertension. Unlike with slow infusion, neither the second tachycardie nor the third systemic hypotensive phases were evident Conclusions - 5-HT induces dose-dependent cardiovascular responses, including a reflex response followed by pulmonary and systemic vasoconstriction, in healthy calves Clinical Relevance - Determining the type of serotonergic receptors responsible for these responses may help to determine whether 5-HT is involved in the mechanisms underlying brisket disease in cattle.