Bilirubin metabolism & pathophysiology of neonatal jaundice

Abstract

Jaundice is a visible yellowish color change in skin and sclera, secondary to elevated serum bilirubin which accumulates in the skin. Visibility of jaundice depends upon the age of the patient, color/complexion of the skin and level of bilirubin in blood. It is more easily visible in fair complexioned and new born (particularly, pre term) babies. In the new born, jaundice is visible during the 1 week of life in 60% of full term and 80% preterm infants.