Analytical study of effects of Magnesium sulphate on pressor response during laryngoscopy and intubation

Abstract

Background: Induction of general anaesthesia and endotracheal intubation for maintenance of airway and prevention of aspiration is carried out frequently by the anesthesiologist in day to day practice. This study was aimed to study the effects of Magnesium sulphate on pressor response during laryngoscopy and intubation. Methods: It was carried out in 50 patients of both sexes, between the age group of 20-60 years, belonging to ASA physical status grade I and II. Magnesium sulphate 50mg Kg-1 given intravenously 60 seconds before intubation and the pressor response to laryngoscopy and intubation assessed. Results: Magnesium  sulphate 50mg Kg-1 given intravenously 60 seconds before intubation, attenuated the pressor response to laryngoscopy and intubation to a significant level, except transient mild tachycardia, which at  the end of 5 minutes settled  back to near pre-induction value. Conclusions: We conclude that magnesium sulphate is superior for attenuation of pressor response to laryngoscopy and intubation.