A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity.
CITATION STYLE
Bergsagel, P. L., & Michael Kuehl, W. (2020, November 1). Promiscuous Structural Variants Drive Myeloma Initiation and Progression. Blood Cancer Discovery. American Association for Cancer Research Inc. https://doi.org/10.1158/2643-3230.BCD-20-0170
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