Association of vitamin B 6, vitamin B 12 and methionine with risk of breast cancer: A dose-response meta-analysis

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Abstract

Background:Epidemiological studies evaluating the association of vitamin B 6, vitamin B 12 and methionine with breast cancer risk have produced inconsistent results.Methods:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed by restricted cubic spline.Results:The combined relative risk (95% confidence interval) of breast cancer for the highest vs lowest category of serum pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels and dietary methionine intake was 0.80 (0.66-0.98, P=0.03) and 0.94 (0.89-0.99, P=0.03), respectively, and the associations of breast cancer with higher serum PLP levels and dietary methionine intake were significant among post-menopausal women, but not among pre-menopausal women. The inverse association between breast cancer risk and dietary vitamin B 6 intake, serum vitamin B12 levels and dietary vitamin B 12 intake was not significant overall. Linear dose-response relationship was found, and the risk of breast cancer decreased by 23% (P<0.00) for every 100 pmol ml-1 increment in PLP levels and 4% (P=0.05) for every 1 g per day increment in dietary methionine intake, respectively.Conclusion:Serum PLP levels and methionine intake might be inversely associated with breast cancer risk, especially among postmenopausal women, which need to be confirmed. © 2013 Cancer Research UK.

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Wu, W., Kang, S., & Zhang, D. (2013). Association of vitamin B 6, vitamin B 12 and methionine with risk of breast cancer: A dose-response meta-analysis. British Journal of Cancer, 109(7), 1926–1944. https://doi.org/10.1038/bjc.2013.438

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