The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.
CITATION STYLE
Marcos, C. M., De Oliveira, H. C., Assato, P. A., De Andrade, C. R., Fusco-Almeida, A. M., & Mendes-Giannini, M. J. S. (2019). Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model. Medical Mycology, 57(7), 900–904. https://doi.org/10.1093/mmy/myy112
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