Impaired Cardiac Sympathetic Nerve Function in Patients with Kawasaki Disease: Comparison with Myocardial Perfusion

Abstract

Kawasaki disease (KD) is a leading cause of CAD in children. The impairment of cardiac sympathetic nerve function (CSNF) in the adult patients with coronary artery disease (CAD) could often be seen. However, little is known concerning the impairment of CSNF in KD patients. We investigated CSNF and its relationship with myocardial perfusion in KD patients. Eleven children with KD and 4 controls were studied with123I-metaiodobenzylguanidine (MIBG) and stressed201Tl single photon emission computed tomography. By the findings on coronary artery angiography (CAG), the patients were divided into 2 groups: A, without stenosis; B, with significant stenosis and/or old myocardial infarction. CSNF was evaluated from the uptake of123I-MIBG. While myocardial perfusion was evaluated from201Tl uptake. The numbers of patients in the groups A and B were 7 and 4. Perfusion defect was found in 0, and 2 patients in group A (0%), and B (50%).123I-MIBG defects were found in 1 and 4 patients in the group A (14%) and B (100%). There were excellent concordances between the finding of201Tl and123I-MIBG in group A. While in group B, the coronary territories with123I-MIBG defects were significantly more than those with perfusion defects (p“ 0.05). In KD patients, the impairment of CSNF might be subsequent to coronary artery stenosis and was more severe than the injury of myocardial perfusion. Abbreviations CADcoronary artery disease CAGcoronary artery angiography CSNFcardiac sympathetic nerve function FWHMfull width of half maximum KDKawasaki disease LVleft ventricle MIBGmetaiodobenzylguanidine NEnorepinephrine SPECTsingle photon emission computed tomography. © International Pediatrics Research Foundation, Inc. 2005. All Rights Reserved.