CSF-1 in Inflammatory and Arthritic Pain Development

  • Saleh R
  • Lee M
  • Khiew S
  • et al.
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Abstract

Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, also known as M-CSF, acts via its receptor (CSF-1R, c-Fms) to regulate the development of the monocyte/macrophage lineage and to act locally in tissues to control macrophage numbers and function. It has been implicated in the control of neuropathic pain via a central action on microglia. We report in this study that systemic administration of a neutralizing anti–CSF-1R or CSF-1 mAb inhibits the development of inflammatory pain induced by zymosan, GM-CSF, and TNF in mice. This approach also prevented but did not ameliorate the development of arthritic pain and optimal disease driven by the three stimuli in mice, suggesting that CSF-1 may only be relevant when the driving inflammatory insults in tissues are acute and/or periodic. Systemic CSF-1 administration rapidly induced pain and enhanced the arthritis in an inflamed mouse joint, albeit via a different pathway(s) from that used by systemic GM-CSF and TNF. It is concluded that CSF-1 can function peripherally during the generation of inflammatory pain and hence may be a target for such pain and associated disease, including when the clinically important cytokines, TNF and GM-CSF, are involved. Our findings have ramifications for the selection and design of anti–CSF-1R/CSF-1 trials.

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APA

Saleh, R., Lee, M.-C., Khiew, S. H., Louis, C., Fleetwood, A. J., Achuthan, A., … Hamilton, J. A. (2018). CSF-1 in Inflammatory and Arthritic Pain Development. The Journal of Immunology, 201(7), 2042–2053. https://doi.org/10.4049/jimmunol.1800665

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