Comparing genetic programming and evolution strategies on inferring gene regulatory networks

Abstract

In recent years several strategies for inferring gene regulatory networks from observed time series data of gene expression have been suggested based on Evolutionary Algorithms. But often only few problem instances are investigated and the proposed strategies are rarely compared to alternative strategies. In this paper we compare Evolution Strategies and Genetic Programming with respect to their performance on multiple problem instances with varying parameters. We show that single problem instances are not sufficient to prove the effectiveness of a given strategy and that the Genetic Programming approach is less prone to varying instances than the Evolution Strategy. © Sringer- Verlag Berlin Heidelberg 2004.