Use of microwave method for controlling drug release of modified sprouted rice starch

Abstract

The study aimed to investigate a new method of thermal modification which was microwave method for controlling drug release of rice starch. The Vibigaba sprouted rice starch (Vietnam) was selected as the model rice. The rice was thermally modified in water for a determined time at different power. The rice starch was first ground and sieved. Then, the powder was physically modified by heat via the microwave and finally dried in an oven. Tablets containing the modified sprouted rice starch of Paracetamol were prepared by the wet granulation method. The dissolution rate of tablets was evaluated in simulated gastric fluid without pepsin (buffer pH 1.2). The matrix tablet containing thermally modified sprouted rice starch showed a sustained release, indicating that the sprouted rice under microwave method could be a promising material for a sustained release dosage form.