Methallyl isothiocyanate

Abstract

(A) Reaction with Arylhydrazines: Richter and co-workers found that MAITC reacts with substituted arylhydrazines to 1,4- or 2,4-disubstituted thiosemicarbazides, depending on the reaction conditions and the nature of the aryl group.6 A derivative of methallyl thiosemicarbazide can be used as sensor element suitable for colorimetric detection of anions.7 (B) Derivatization of Heterocycles: Merla and co-workers patented a method for the synthesis of substituted benzo[d]isoxazol-3-yl-N′-methallyl thioureas which exhibit an strong affinity for the KCNQ2/3 K+ channel and which are suitable for relieving pain.8 MAITC is a reagent for the synthesis of thioureido- substituted spiro compounds which can be used for the production of producing pain-relief medicaments.9 A new thiourea derivative of 1,2,4-triazole has been synthesized and tested as a possible drug. It was shown that the thiourea with the endocyclic Natom forms selectively.10. © Georg Thieme Verlag Stuttgart, New York.