Ultrasonic assisted synthesis of naphthalene substituted Schiff base derivatives and their antioxidant activity studies

Abstract

New Schiff base derivatives, 2,2′-[naphthalene-2,7-diylbis(oxy)] bis[N′-substituted acetohydrazide] (4a-m) were synthesized by the acid catalyzed condensation of aryl/hetero aromatic aldehydes with 2,2′- [naphthalene-2,7-diylbis(oxy)]diacetohydrazide (3) under reflux temperature and ultrasonic irradiation. These Schiff base derivatives were confirmed through spectral characterization using IR, 1H NMR, 13C NMR and mass spectra. All the synthesized compounds were screened for their antioxidant activity using DPPH free radical scavenging method.