Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study

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Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the increasing proportion of nano-based vaccines, this review compiles and analyses how COVID-19 and nanoparticles affect lipids, amino acids, and carbohydrates metabolism. A search was conducted on PubMed, ScienceDirect, Web of Science for available information on the interrelationship between metabolomics and immunity in the context of SARS-CoV-2 infection and the effect of nanoparticles on metabolite levels. It was clear that SARS-CoV-2 disrupted several pathways to ensure a sufficient supply of its building blocks to facilitate its replication. Such information can help in developing treatment strategies against viral infections and COVID-19 based on interventions that overcome these metabolic changes. Furthermore, it showed that even drug-free nanoparticles can exert an influence on biological systems as evidenced by metabolomics. Graphical abstract: [Figure not available: see fulltext.].

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El-Derany, M. O., Hanna, D. M. F., Youshia, J., Elmowafy, E., Farag, M. A., & Azab, S. S. (2023, October 1). Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study. Pharmacological Reports. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s43440-023-00517-w

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