Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.
CITATION STYLE
Zitnik, G., Chandler, D. J., & Waterhouse, B. D. (2016). Norepinephrine and synaptic transmission in the cerebellum. In Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students (pp. 237–241). Springer International Publishing. https://doi.org/10.1007/978-3-319-24551-5_30
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