A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

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Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains. © 1990 Nature Publishing Group.

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Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Münsterberg, A., … Lovell-Badge, R. (1990). A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature, 346(6281), 245–250. https://doi.org/10.1038/346245a0

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