Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia

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Abstract

The voltage-gated sodium channel NaV1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia (DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found a novel splice variant lacking exon 11, which codes for 98 amino acids of the domain I/II linker. Quantitative PCR analysis revealed an abundance of this variant of up to 5-10% in human, while no such variants were detected in mouse or rat. Since no obvious functional differences between channels with and without the exon-11 sequence were detected, it is suggested that SCN10A exon 11 skipping in humans is a tolerated event. © 2014 Landes Bioscience.

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Schirmeyer, J., Szafranski, K., Leipold, E., Mawrin, C., Platzer, M., & Heinemann, S. H. (2014). Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia. Channels, 8(3), 210–215. https://doi.org/10.4161/chan.28146

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