Determination of Ocular Blood Flows with the Microsphere Method

Abstract

The basic principle of the microsphere method is simple; microspheres injected into the systemic circulation are distributed and entrapped in tissues in proportion to the blood fl ow through the tissues. Although various types of solid particles had been used to study the microcirculation previously (see [36]), it was the introduction of plastic radioactive microspheres (RM) that boosted interest in the method. Rudolph and Heymann [77] were the fi rst to use RM to study the blood fl ow distribution in the fetus of sheep and goat.