Ephrin A1-targeted nanoshells for photothermal ablation of prostate cancer cells

94Citations
Citations of this article
62Readers
Mendeley users who have this article in their library.

Abstract

Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them. to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA1, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser. © 2008 Gobin et al, publisher and licensee Dove Medical Press Ltd.

Cite

CITATION STYLE

APA

Gobin, A. M., Moon, J. J., & West, J. L. (2008). Ephrin A1-targeted nanoshells for photothermal ablation of prostate cancer cells. International Journal of Nanomedicine, 3(3), 351–358. https://doi.org/10.2147/ijn.s2810

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free