This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis. Prolonged treatment with T-0681 increased the hepatic expression of both LDL receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Upregulation of hepatic lipoprotein receptors was accompanied by a marked decrease of apolipoprotein B-containing lipoproteins, reflected by a 60% reduction of plasma cholesterol and a ≥70% reduction of plasma triglyceride levels. Most importantly, T-0681 reduced the development of atherosclerosis by 80% in NZW rabbits on high-cholesterol chow. Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans. Copyright © 2009 by the American Society for Biochemistry and Molecular Biology, Inc.
CITATION STYLE
Tancevski, I., Wehinger, A., Demetz, E., Hoefer, J., Eller, P., Huber, E., … Ritsch, A. (2009). The thyromimetic T-0681 protects from atherosclerosis. Journal of Lipid Research, 50(5), 938–944. https://doi.org/10.1194/jlr.M800553-JLR200
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