vitreous proteins

Abstract

The overall protein concentration in human vitreous is between 0.5 and 1 mg/ml. Proteomic analyses have identified a large number of proteins in vitreous. For example, a 2013 study by Aretz et al. [1] identified over a 1,000 proteins in vitrectomy samples from three human subjects, and 261 of these proteins were consistently identified in all three samples. The embryonic human vitreous proteome has also been studied with the aim of identifying changes (up as well as down regulation) that could be related to the regression the hyaloid vasculature during the second trimester. This study also identified 1,000 unique proteins, with 296 changing between 2- and 100-fold during the second trimester (66 upregulated, 230 down regulated).