Chemical properties of myxococcus xanthus antibiotic ta

Abstract

Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (λmax239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity. © 1982, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.