The study of dynamics of clinical and molecular phenotypes in the generalized form of myasthenia with optimized and combined treatment

Abstract

The aim of the study was the research of clinical and molecular phenotypes in the generalized form of myasthenia with optimized treatment, which includes the application of basic mode of the treatment and meglumine sodium succinate, and also the combined mode of the treatment, which includes the application of basic mode of the treatment and meglumine sodium succinate and ozpnotherapy. The most expressed improvement of indicators of the clinical and neurologic status (the elimination of motoring breakdown, eye movement disorders, the weaknesses of mimic, respiratory and chewing muscles, bulbar syndrome, the doubling in eyes and ptosis, pharyngeal violations and increase in volume of movement of eyes) was observed in the group of patients receiving the combined therapy. The reduction of the expressiveness of the defeat of the neuromotor device and the decrement of the amplitude of the various degree of M-answer inpatients with myasthenia is revealed In the application of the combined therapy in the comparison with the application of die basic and optimized therapy. For the first time we have investigated the dynamics of the intensity of the expression of specific peptides and proteins in blood serum In patients with the application of basic therapy, reamberln and ozpnotherapy, which have allowed to open the new mechanisms of the efficiency of the combined therapy of the disease.