El nuevo paradigma de la hemocromatosis neonatal: Hepatitis fetal aloinmunitaria

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Abstract

The classical model of neonatal hemochromatosis was based on the analogy with hereditary hemochromatosis. Medical treatment consisted on the antioxidant-chelator cocktail. The new hypothesis of an alloimmune origin of the process by which the pregnant woman mounts an IgG-based destructive response against fetal hepatocytes offers a pathogenic explanation, allowing treatment to be focused on the immunological aspects, with excellent results, and opens the possibility of preventive treatment in future pregnancies. This new paradigm produces a deep impact in diagnosis, prognosis and treatment of the disease, that should be called "fetal alloimmune hepatitis".

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Costaguta, A., & Álvarez, F. (2012, May). El nuevo paradigma de la hemocromatosis neonatal: Hepatitis fetal aloinmunitaria. Archivos Argentinos de Pediatria. https://doi.org/10.5546/aap.2012.237

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